Regimen Lab Skincare Encyclopedia ?

Hesperidin Methyl Chalcone

*Preliminary Lab Notes* - Full Entry Under Development

Ingredient Profile

Common Name: Hesperidin Methyl Chalcone, HMC
INCI: Hesperidin Methyl Chalcone
Source: Orange peel
Hesperidin Methyl Chalcone Molecule

kligman ingredient evaluation

Penetration: Under analysis
Biochemical Mechanism: Under analysis
Level of Evidence: Under analysis

Regimen's Take

Hesperidin Methyl Chalcone (HMC) is a flavonoid derived from citrus. In skincare, it's primarily used as an antioxidant, and also has noted effects on circulation (used to reduce dark circles), and has been shown to have effects on melanin synthesis. Because hesperidin it it's raw form has poor absorption, it's modified into HMC to allow for better stability and skin compatibility. Hesperidin has been shown to reverse side effects caused by the use of topical steroids (for those with eczema or other skin conditions) -reduces bag volume 65% -stimulates proflieration. Fun fact: fermented citrus peels were tested on skin to see what would happen, even subjected to UV, skin cells would INCREASE collagen (whereas normally it is decreased by UV exposure) Like all flavonoids, HMC is a highly complex compound typically found in bright coloured plants/flowers, and has strong free radical quenching properties.


Products that use Hesperidin Methyl Chalcone should have a strong yellow color. Anything less is a giveaway that the product does not contain enough of the ingredient! When using products, ensure the solution has some penetration enhancers, otherwise HMC could end up drying as a powder on the surface of your skin.
Hesperidin Methyl Chalcone
The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.