|Common Name: Epigallocatechin gallate (EGCG)|
|INCI: Epigallocatechin gallate (EGCG)|
|Source: Green Tea|
kligman ingredient evaluation
|Penetration: Under analysis|
|Biochemical Mechanism: Under analysis|
|Level of Evidence: Under analysis|
- Studies have shown effective levels of EGCG at .5% - 1% but it may be effective at lower or higher levels
- Don't confuse EGCG with Green Tea Extract! Extracts vary wildly in the concentration of actives, and many are found to include over 90% water. This is why pure compounds are strongly preferred in skincare.
The full Regimen Lab Skincare Encyclopedia Entry for Ceramides is in development. Check back in a few weeks for an update!
What is Epigallocatechin gallate?
Epigallocatechin-3-gallate (EGCG) is a major catechin polyphenolic compound.
How it works
Inhibition of the erythema response evoked by UV radiation.
The phenol rings in EGCG structure act as electron traps and scavengers of free radicals, inhibit the formation of reactive oxygen species, and reduce the harm caused by oxidative stress.
EGCG inhibits the transfection of NF-B and AP-1 to downregulate the expression of iNOS and COX-2 mainly by scavenging NO, peroxynitrite, and other ROS/RNS and decreases the production of inflammatory factors to show the anti-inflammatory effects.
Antioxidant and anti-inflammatory effects, cancer chemoprevention, protecting the skin from the damage caused by ionizing radiation, hydration, moisture retention, and wrinkle formation.
Clinical trials and sources:
https://www.ncbi.nlm.nih.gov/pubmed/8570723/ - Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols.
https://www.ncbi.nlm.nih.gov/pubmed/11209110 - Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796122/ - Skin Protective Effect of Epigallocatechin Gallate.
https://www.tandfonline.com/doi/full/10.1080/10717544.2016.1228718 - Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage.
https://www.degruyter.com/downloadpdf/j/acph.2014.64.issue-2/acph-2014-0017/acph-2014-0017.pdf - In vivo human skin penetration of (–)-epigallocatechin-3-gallate from topical formulations.